5HT1A Receptor Antibody | R30731

5HT1A Receptor Antibody | R30731 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC-P

Buffer: N/A

Limitation: This 5HT1A Receptor antibody is available for research use only.

Purity: Antigen affinity

Description: 5HT1AR is a subtype of 5HTR that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. The HTR1A gene is located at 5q12.3. The decreases in 5HT1AR densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5HT1ARs has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. In the dorsal raphe nucleus they are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Immunogen: An amino acid sequence from the C-terminus of human 5HT1A Receptor(NKDFQNAFKKIIKCKFCRQ) was used as the immunogen for this 5HT1A Receptor antibody.

Storage: After reconstitution, the 5HT1A Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.