XRCC4 Monoclonal Antibody | E-AB-22044

XRCC4 Monoclonal Antibody | E-AB-22044 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Mouse

Isotype: IgG

Application: WB, IHC-p, IF, IP

Research Area: Cancer, Epigenetics and Nuclear Signaling

Background: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300

Conjugation: Unconjugated

Calculated Molecular Weight: 38 kDa

Observed Molecular Weight: 38 kDa

Clonality: Monoclonal