Description
XAB1 Antibody | V3826-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: GPN1/2350
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: ELISA, WB
Buffer: N/A
Limitation: This XAB1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: GPN1 (GPN-loop GTPase 1), also called XAB1 (XPA-binding protein 1) is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating it in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that it has possible GTPase activity.
Immunogen: Recombinant full length human protein was used as the immunogen for this XAB1 antibody.
Storage: Store the XAB1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
