VDR Antibody / Vitamin D Receptor | RQ5366

VDR Antibody / Vitamin D Receptor | RQ5366 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: AAGE-22

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human, Mouse

Application: WB

Buffer: N/A

Limitation: This Vitamin D Receptor antibody is available for research use only.

Purity: Affinity purified

Description: The VDR gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [RefSeq]

Immunogen: A synthetic peptide specific to human Vitamin D Receptor / VDR was used as the immunogen for the Vitamin D Receptor antibody.

Storage: Store the Vitamin D Receptor antibody at -20 °C.