Description
VDAC1 Antibody | R30873 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P, IHC-F, ICC
Buffer: N/A
Limitation: This VDAC1 antibody is available for research use only.
Purity: Antigen affinity
Description: The voltage-dependent anion channel of the outer mitochondrial membrane is a small, abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic mitochondria. The protein is though to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase. At low transmembrane voltage, VDAC1 is open for anions such as phosphate, chloride, and adenine nucleotides. At higher transmembrane voltage, VDAC1 functions as a selective channel for cations and uncharged molecules. These features make it likely the protein plays a role in mitochondrial energy metabolism. Huizing et al. studied by Northern and Western blot analyses the human tissue distribution of mitochondrial transmembrane metabolite carriers. VDAC1 mRNA has a ubiquitous distribution, with most pronounced expression in heart, liver, and skeletal muscle, whereas the VDAC2 isoform appears to be expressed only in the heart.
Immunogen: An amino acid sequence from the middle region of human Voltage-dependent anion channel 1 (RVTQSNFAVGYKTDEF) was used as the immunogen for this VDAC1 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the VDAC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
