Description
VDAC1 Antibody | F49743-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, FACS, ELISA
Buffer: N/A
Limitation: This VDAC1 antibody is available for research use only.
Purity: Purified
Description: VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Immunogen: A portion of amino acids 95-124 from the human protein was used as the immunogen for this VDAC1 antibody.
Storage: Aliquot the VDAC1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
