VDAC Antibody | F49742-0.4ML

VDAC Antibody | F49742-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC, FACS, ELISA

Buffer: N/A

Limitation: This VDAC antibody is available for research use only.

Purity: Antigen affinity

Description: VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Immunogen: A portion of amino acids 1-30 from human VDAC1 was used as the immunogen for this VDAC antibody.

Storage: Aliquot the VDAC antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.