USP2 Antibody | F53953-0.05ML

USP2 Antibody | F53953-0.05ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 1738CT331.50.87

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, African Green Monkey

Application: WB

Buffer: N/A

Limitation: This USP2 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Ubiquitin carboxyl-terminal hydrolase 2 is a hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Immunogen: A partial recombinant protein corresponding to amino acids 1-258 from the human protein was used as the immunogen for the USP2 antibody.

Storage: Aliquot the USP2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.