Description
Universal IDO1/IDO2/TDO Inhibitor Screening Assay Kit | 72035 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Assay Kit
Application: Useful for the study of IDO1, IDO2, and TDO enzymology, screening inhibitors, and selectivity profiling.
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2) and Tryptophan 2,3 dioxygenase (TDO) are upregulated in many tumors, providing cancer cells with an avenue for immune evasion.
Description: The Universal IDO1/IDO2/TDO Inhibitor Screening Assay Kit is designed to measure IDO1, IDO2 and TDO enzyme inhibition.
Product Type: Assay Kit
Shippement Condition: -80°C (dry ice)
