Description
ULK1 Kinase Assay Kit | 78362 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Assay Kit
Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and High Throughput (HTS) applications.
Background: ULK1 (unc-51 like autophagy activating kinase 1) is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy in response to nutrient starvation. The conserved C-terminal domain of ULK1 controls the function and the localization of the protein. Knockdown of ULK1 inhibits the autophagic response and prevents rapamycin-induced autophagy, consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy (1). Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of the ULK1 protein (2). ULK1 is phosphorylated upon activation of the mTOR pathway in a nutrient starvation-regulated manner. Alterations in ULK signaling pathways may be involved in the formation of autophagy-regulated Lewi bodies, which have been associated with Parkinson's disease (3).
Description: The ULK1 Kinase Assay Kit is designed to measure ULK1 activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent.
Product Type: Assay Kit
Shippement Condition: -80°C
