Description
ULK1, FLAG-tag | 40099 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Description: Human ULK1 (UNC-51-Like Kinase-1), also known as ATG1 (Autophagy related protein 1), GenBank Accession No. NM_003565, a.a. 2-end with N-terminal FLAG-tag, MW = 113 kDa, expressed in FreeStyle 293-F cells.
Product Type: Protein
Shippement Condition: -80°C
