Description
UBE2C, His-Tag | 79369 | Gentaur US, UK & Europe Disrtribition
Category: Ubiquitination/Activating Enzyme (E1)
Application: Useful for the study of ubiquitin enzyme kinetics, and as a positive control for Western blot studies.
Background: UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C.
Description: Recombinant full-length Human UBE2C, also known as UBCH10. Genbank Accession No. NM_007019, with an N-terminal His-tag, expressed in E. coli. MW=21 kDa.
Product Type: Protein
Shippement Condition: -80°C
