TYSY Antibody / Thymidylate Synthase | F54872-0.4ML

TYSY Antibody / Thymidylate Synthase | F54872-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IF, FACS, IHC-P

Buffer: N/A

Limitation: This TYSY antibody is available for research use only.

Purity: Antigen affinity purified

Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Immunogen: A portion of amino acids 265-294 from the human protein was used as the immunogen for the TYSY antibody.

Storage: Aliquot the TYSY antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.