TXNIP Polyclonal Antibody | E-AB-17496

TXNIP Polyclonal Antibody | E-AB-17496 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: IHC, ELISA

Research Area: Cancer, Cell biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Lead Time: 7~10 days

Concentration: 1.9 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human TXNIP

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification: Affinity purification

Dilution: IHC 1:30-150, ELISA 1:2000-10000

Conjugation: Unconjugated

Calculated Molecular Weight: N/A

Observed Molecular Weight: N/A

Clonality: Polyclonal