TTR Monoclonal Antibody | E-AB-22254

TTR Monoclonal Antibody | E-AB-22254 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Mouse

Isotype: IgG

Application: WB, IHC-p

Research Area: Cancer, Cardiovascular, Neuroscience

Background: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Protein of TTR

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification: Protein A purification

Dilution: WB 1:500-2000, IHC 1:50-300

Conjugation: Unconjugated

Calculated Molecular Weight: N/A

Observed Molecular Weight: 16 kDa

Clonality: Monoclonal