TSLP [Biotinylated]: IL-7Rα & TSLP R Inhibitor Screening ELISA Kit | EP-129-96tests

TSLP [Biotinylated]: IL-7Rα & TSLP R Inhibitor Screening ELISA Kit | EP-129| Gentaur Distribution US, UK & Europe

Thymic stromal lymphopoietin (TSLP) exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7Rα.The formation of the ternary complex, TSLPR: TSLP: IL-7Rα, initiates signaling in cells co-expressing TSLPR and IL-7Rα.TSLP has been implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis) . Therefore, inhibition of TSLP interaction with TSLP receptor complex has been considered a promising strategy to blocks thymic stromal lymphopoietin (TSLP) function and prevents the overreactive immune response to allergic, eosinophilic and other types of airway inflammation associated with severe asthma.

Source: Thymic stromal lymphopoietin (TSLP) exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7Rα.The formation of the ternary complex, TSLPR: TSLP: IL-7Rα, initiates signaling in cells co-expressing TSLPR and IL-7Rα.TSLP has been implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis) . Therefore, inhibition of TSLP interaction with TSLP receptor complex has been considered a promising strategy to blocks thymic stromal lymphopoietin (TSLP) function and prevents the overreactive immune response to allergic, eosinophilic and other types of airway inflammation associated with severe asthma.

Molecule: ILN/A7 R alpha & TSLP R.

Format: Solid.

Species: Human.

Application: This kit is developed for screening for inhibitors of TSLP binding to human IL-7Rα & TSLP R.

Kit Component: This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new TLSP pathway inhibitors. The assay takes advantage of our in house-developed binding of biotinylated human TLSP to immobilized human IL-7 R alpha & TSLP R in a functional ELISA assay, and employs a simple colorimetric sandwich ELISA platform.

Stability: The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

Storage Conditions: 2-8℃.

Shipping Conditions: RT