Description
TrkA / SRE Reporter - HEK293 Recombinant Cell Line | 79798 | Gentaur US, UK & Europe Disrtribition
Category: Neuroscience/Cell Line
Application: • Screen for inhibitors of NGF/TrkA signaling in a cellular context • Screen for inhibitors of TrkA kinase activity in a cellular context
Background: A chronic pain mediator, NGF (Nerve Growth Factor) binds to TrkA resulting in activation of the downstream signaling pathway linked to pro-nociception; therefore, targeting the kinase activity of TrkA and the interaction between NGF/TrkA have been attractive tools in pain management research. In addition to control of chronic pain, a recent clinical success has proven that inhibition of TrkA kinase would be a promising anti-cancer strategy.
Description: Recombinant HEK-293 cells expressing firefly luciferase gene under the control of Serum Response Elements (SRE) with constitutive expression of human TrkA (Tropomyosin receptor kinase A; NTRK1; ref. seq. NM_002529.3).
Product Type: Cell Line
Shippement Condition: -80°C
