TrkA Antibody (NTRK1) | F50682-0.08ML

TrkA Antibody (NTRK1) | F50682-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, FACS, ELISA

Buffer: N/A

Limitation: This TrkA antibody is available for research use only.

Purity: Antigen affinity

Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Isoform 3 is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. [Isoform 3 information courtesy of UniProt].

Immunogen: A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody.

Storage: Store at 4oC for up to one month. For long term, aliquot the TrkA antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.