Topoisomerase II alpha Antibody / TOP2A | V7245-20UG

Topoisomerase II alpha Antibody / TOP2A | V7245-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: TPM2A-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IF, IHC

Buffer: N/A

Limitation: This TOP2A antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This mAb recognizes a 170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.

Immunogen: Human recombinant partial protein (amino acids 1352-1493) was used as the immunogen for this TOP2A antibody.

Storage: Store the TOP2A antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).