Description
Topoisomerase II alpha Antibody / TOP2A | V3443SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: TOP2A/1361
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse
Application: IF, WB, IHC-P
Buffer: N/A
Limitation: This Topoisomerase II alpha antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: This mAb recognizes an ~170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
Immunogen: Amino acids 1352-1493 from the human protein were used as the immunogen for this Topoisomerase II alpha antibody.
Storage: Store the Topoisomerase II alpha antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
