TOP1MT Antibody / Topoisomerase I mitochondrial | V2461IHC-7ML

TOP1MT Antibody / Topoisomerase I mitochondrial | V2461IHC-7ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Format: Purified

Clone: TOP1MT/488

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This TOP1MT antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

Immunogen: Recombinant full-length human protein was used as the immunogen for the TOP1MT antibody.

Storage: Store the TOP1MT antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).