Description
TNIK Kinase Assay Kit | 78370 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Assay Kit
Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: TNIK (TRAF2 and NCK interacting kinase) is characterized by an N-terminal kinase domain and a C-terminal GCK domain (Germinal Center Kinase domain) that serves a regulatory function (1). TNIK is mainly expressed in the brain, heart, and spleen. It is a specific effector of RAP2 (RAP2A, member of RAS oncogene family), which regulates the actin cytoskeleton (2). TNIK autophosphorylation depends upon Lys54 in the ATP-binding pocket of its kinase domain and plays a major role in cytoskeleton regulation.
Description: The TNIK Kinase Assay Kit is designed to measure TNIK kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Product Type: Assay Kit
Shippement Condition: -80°C
