TNFSF11: RANK Inhibitor Screening ELISA Kit | EP-144-96tests

TNFSF11: RANK Inhibitor Screening ELISA Kit | EP-144| Gentaur Distribution US, UK & Europe

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

Source: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

Molecule: TNFSF11.

Format: Solid.

Species: Human.

Application: This kit is developed for screening for inhibitors of human TNFSF11 binding to human RANK.

Kit Component: This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new TNFSF11 pathway inhibitors. The assay takes advantage of our in house-developed binding of HRP-human RANK to immobilized human TNFSF11 in a functional ELISA assay, and employs a simple colorimetric ELISA platform. Briefly, we provide you with a HRP-human RANK, a human TNFSF11 protein, an anti-TNFSF11 neutralizing antibody (as method verified Std.) .

Stability: The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

Storage Conditions: 2-8℃.

Shipping Conditions: RT