Description
TNF alpha Antibody Cocktail | V2904-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: TNF706 + P/T2
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P
Buffer: N/A
Limitation: This TNF-alpha antibody cocktail is available for research use only.
Purity: PEG precipitation
Description: TNF alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha causes cytolysis of certain transformed cells. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Immunogen: An N-terminal recombinant protein fragment (TNF706) and amino acids 115-130 (NGVELRDNQLVVPSEG) were used as the immunogen for the TNF-alpha antibody cocktail.
Storage: Store the TNF-alpha antibody cocktail at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
