TMIGD2/NFAT Luciferase Reporter Jurkat Cell Line | 78323

TMIGD2/NFAT Luciferase Reporter Jurkat Cell Line | 78323 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: • Characterize the biological activity of TMIGD2 interaction with B7-H7 • Screen for B7-H7 antibodies in co-culture with B7-H7-expressing cells

Background: HHLA2 (B7-H7) mediates an immune-stimulatory signal via TMIGD2 in naive T cells while it delivers an immune-inhibitory signal through KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains and Long Cytoplasmic Tail 3) in activated T cells and Natural Killer (NK) cells.

Description: Recombinant Jurkat cell line expressing firefly luciferase under the control of an NFAT response element, and with constitutive expression of human TMIGD2 (Transmembrane and immunoglobulin domain containing 2; CD28H; NM_144615). Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity. 

Product Type: Cell Line

Shippement Condition: -80°C