TLR7 Antibody | R30823

TLR7 Antibody | R30823 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Rat, Mouse

Application: WB, IHC-P

Buffer: N/A

Limitation: This TLR7 antibody is available for research use only.

Purity: Antigen affinity

Description: Toll-like receptor 7 is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. It is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Immunogen: An amino acid sequence from the C-terminus of human TLR7 (QAHPYFWQCLKNALATDNH) was used as the immunogen for this TLR7 antibody.

Storage: After reconstitution, the TLR7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.