TLK2, GST-tag | 40287

TLK2, GST-tag | 40287 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly (1). In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication.

Description: Recombinant human TLK2 (a.a. 388-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C