Description
TIGIT (Mouse): CD155 (Mouse) Homogeneous Assay Kit | 78141 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Assay Kit
Application: Useful for screening for inhibitors of TIGIT binding to CD155.
Background: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a receptor that is expressed on the surface of T cells and NK cells that binds to CD155 and CD112 on the surface of dendritic cells. Binding of TIGIT with CD155 or CD112 results in inhibition of T cell and NK cell activation. Antibodies and other agents that inhibit this signaling pathway have been shown to increase the immune response, especially in the case of certain cancers.
Description: The Mouse TIGIT: Mouse CD155 (mTIGIT:mCD155) Homogeneous Assay Kit is designed to measure the inhibition of mTIGIT binding to mCD155. With this kit, only three simple steps on a microtiter plate are required. First, a sample containing mTIGIT and an inhibitor of choice is incubated with the mCD155 for 60 minutes. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
Product Type: Assay Kit
Shippement Condition: -80°C
