TICAM1 Antibody | F52327-0.4ML

TICAM1 Antibody | F52327-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This TICAM1 antibody is available for research use only.

Purity: Antigen affinity

Description: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Immunogen: A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.

Storage: Aliquot the TICAM1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.