Description
Thymidylate Synthase Antibody | V7622SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: TYSY9-2
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P, WB, IF
Buffer: N/A
Limitation: This Thymidylate Synthase antibody is available for research use only.
Purity: Protein G purified monoclonal antibody
Description: Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Immunogen: A recombinant human protein from within amino acids 60-174 was used as the immunogen for this Thymidylate synthase antibody.
Storage: Store the Thymidylate synthase antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
