Description
Thymidylate Synthase Antibody | RQ5083 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: ADAA-20
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This Thymidylate Synthase antibody is available for research use only.
Purity: Affinity purified
Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]
Immunogen: A synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.
Storage: Store the Thymidylate Synthase antibody at -20 °C.
