Description
Thymidylate Synthase Antibody | F54315-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P, IF, FACS
Buffer: N/A
Limitation: This Thymidylate Synthase antibody is available for research use only.
Purity: Antigen affinity purified
Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Immunogen: A portion of amino acids 265-294 from the human protein was used as the immunogen for the Thymidylate Synthase Antibody.
Storage: Aliquot the Thymidylate Synthase antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
