Description
TGFB2 Polyclonal Antibody | E-AB-40425 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: WB, IHC
Research Area: Signal Transduction, Stem Cells, Cancer, Metabolism
Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Lead Time: 7~10 days
Concentration: 0.95 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Human Transforming growth factor beta-2 proprotein protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3
Purification: Antigen Affinity Purification
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Conjugation: Unconjugated
Calculated Molecular Weight: 47, 50 kDa
Observed Molecular Weight: 47 kDa
Clonality: Polyclonal
