Description
TGFB1/2/3 Antibody / TGF Beta 1/2/3 | V2889-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: 1D11.16.8
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse, Rat
Application: Cytokine neutralization, Functional assay, ELISA, IF, WB
Buffer: N/A
Limitation: This TGF-beta antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Immunogen: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
Storage: Store the TGF-beta antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
