TFF1 antibody (Estrogen Inducible Protein) | R30775

TFF1 antibody (Estrogen Inducible Protein) | R30775 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Rat

Application: WB, IHC-P

Buffer: N/A

Limitation: This TFF1 antibody is available for research use only.

Purity: Antigen affinity

Description: Trefoil factor 1, also known as Estrogen inducible factor pS2, is a protein that in humans is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. It is found that the protein in normal human urine inhibited the growth of calcium oxalate crystals. Urinary TFF1 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by TFF1 antisera, particularly by antisera directed to the TFF1 C terminus. Concentrations and relative amounts of the protein in the urine of patients with idiopathic calcium oxalate kidney stones were significantly less than those found in controls. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Immunogen: An amino acid sequence from the middle region of mouse Estrogen Inducible Protein pS2 (CCFDDSVRGFPWCF) was used as the immunogen for this TFF1 antibody (100% rat homology).

Storage: After reconstitution, the TFF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.