Description
TDO-HEK293 Recombinant Cell line | 60534 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: Monitor TDO pathway activity. Screen for activators or inhibitors of TDO in a cellular context
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Tryptophan 2,3 dioxygenase (TDO), is upregulated in many tumors, providing cancer cells with an avenue for immune evasion.
Description: Stable recombinant HEK293 cell line expressing human tryptophan 2,3 dioxygenase (TDO2, TDO, TPH2, TRPO), Genbank accession number NM_005651.
Product Type: Cell Line
Shippement Condition: -80°C (dry ice)
