Description
TCR Knockout Jurkat Cell Line | 78539 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: Use as a control when generating or charaterizing CAR-T Cells
Background: The T-Cell Receptor (TCR) is found on the surface of T cells and is responsible for recognizing antigens bound to MHC (Major Histocompatibility Complex) molecules. Engagement of the TCR initiates downstream NFAT signaling resulting in T cell activation. The TCR consists of a heterodimer of two different protein chains, of which the alpha (α) and beta (β) chains are the predominant chains. CRISPR/Cas9 genome editing was utilized to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) regions of the α and β chains, resulting in a loss of TCR expression.
Description: The TCR Knockout Jurkat cell line was generated by CRISPR/Cas9 genome editing to remove the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα and β chains.
Product Type: cell Line
Shippement Condition: -80°C
