Description
Tau-441 (P301L) Protein | 90348 | Gentaur US, UK & Europe Disrtribition
Category: Neuroscience/Protein
Application: Kinase Assay, Western blot
Background: Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases, are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system.
Description: Human Tau-441 with a P301L mutation, GenBank Accession No. P10636-8, full length, expressed in an E. coli expression system. MW = 64 kDa.
Product Type: Protein
Shippement Condition: -80°C
