Description
Tal1(BTL73), 1mg/mL Antibody | BNUM2852-50| Gentaur Distribution US, UK & Europe
Summary.: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .
Conjugate: Purified, BSA-free.
Storage Buffer: PBS, no BSA, no azide.
Storage Temperature: 35°C to -5°C .
Application: CHiP (published)|Flow, intracellular (published)|IHC (published)|IHC, FFPE (published)|EMSA (published).
Stability: Stable at room temperature or 37°C (98°F) for 7 days.
