TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1 | V8108SAF-100UG

TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1 | V8108SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: TAL1/3146

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA

Buffer: N/A

Limitation: This TAL1 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.

Immunogen: A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.

Storage: Store the TAL1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).