Description
TAK1-TAB1, GST-tag | 40279 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP) (1). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 (2). Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation.
Description: Recombinant fusion protein consisting of human proteins TAK1 (TGFβ-activated kinase 1), also known as MAP3K7 (Mitogen-activated protein kinase kinase kinase 7), Genbank Accession #NM_003188, a.a. 1-303, and human TAB1 (TAK1-binding protein), Genbank Accession #NM_006116, a.a. 437-end, linked by a small peptide (DFGGGGG), and with an N-terminal GST-tag, MW = 74 kDa, expressed in Sf9 cells via a baculovirus expression system.
Product Type: Protein
Shippement Condition: -80°C
