SUV39H2 Antibody (KMT1B) | F42487-0.08ML

SUV39H2 Antibody (KMT1B) | F42487-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This SUV39H2 antibody is available for research use only.

Purity: Purified

Description: The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Immunogen: A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.

Storage: Aliquot the SUV39H2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.