Description
SUMO2 Antibody | F52344-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: 973CT8.1.1
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Rat
Application: IF, WB, ELISA
Buffer: N/A
Limitation: This SUMO-2 antibody is available for research use only.
Purity: Purified
Description: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Immunogen: Purified His-tagged protein was used to produced this monoclonal SUMO-2 antibody.
Storage: Aliquot the SUMO-2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
