STRADA Polyclonal Antibody | E-AB-63354

STRADA Polyclonal Antibody | E-AB-63354 | Gentaur US, UK & Europe Disrtribition

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Cancer, Cell Biology, Metabolism, Immunology

Background: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human STRADA (NP_699166.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:1000-1:2000

Conjugation: Unconjugated

Calculated Molecular Weight: 33 kDa/34 kDa/38 kDa/41 kDa/43 kDa/48 kDa

Observed Molecular Weight: 48 kDa

Clonality: N/A