Description
Stefin B Antibody | R31218 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P
Buffer: N/A
Limitation: This Stefin B antibody is available for research use only.
Purity: Antigen affinity
Description: Cystatin B (CSTB), also called Stefin B (STFB), is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The gene is located on 21q22.3. The protein is widely distributed and is localized mostly intracellularly, but has been found extracellularly. It is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is though to be as a protector against the proteinases leaking from lysosomes. A STFB multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, STFB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of the protein is dependent on the differentiation status of the cell.
Immunogen: An amino acid sequence from the middle region of human Stefin B (QLEEKENKKFPVFKAVSFKS) was used as the immunogen for this Stefin B antibody.
Storage: After reconstitution, the Stefin B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
