SREBP1(SREBP1/1578), CF568 conjugate, 0.1mg/mL Antibody | BNC681578-100

SREBP1(SREBP1/1578), CF568 conjugate, 0.1mg/mL Antibody | BNC681578-100| Gentaur Distribution US, UK & Europe

Summary.: The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .

Conjugate: CF568.

Storage Buffer: PBS, 0.1% BSA, 0.05% azide.

Storage Temperature: 2°C to 8°C.

Application: .

Stability: Stable at room temperature or 37°C (98°F) for 7 days.