Description
SREBF1 Antibody | F54996-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: FACS, IHC-P, WB
Buffer: N/A
Limitation: This SREBF1 antibody is available for research use only.
Purity: Antigen affinity purified
Description: SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
Immunogen: A portion of amino acids 349-378 from the human protein was used as the immunogen for the SREBF1 antibody.
Storage: Aliquot the SREBF1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
