SQSTM1 Polyclonal Antibody | E-AB-19884

SQSTM1 Polyclonal Antibody | E-AB-19884 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB, IHC, ELISA

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction

Background: Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate, p62 is degraded during the autophagic process, which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases, including Huntington's disease, Alzheimer's disease, Parkinson's disease in the brain, and nephropathic cystinosis in kidney (22074114, 22860231, 22714671). The molecular weight of p62 is predicted as 48/ 38 kDa, while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.

Lead Time: 7~10 days

Concentration: 1.14 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human SQSTM1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000

Conjugation: Unconjugated

Calculated Molecular Weight: 48 kDa

Observed Molecular Weight: Refer to figures

Clonality: Polyclonal