SPHK1 Antibody | F40149-0.4ML

SPHK1 Antibody | F40149-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, FACS, IHC, ELISA

Buffer: N/A

Limitation: This SPHK1 antibody is available for research use only.

Purity: Purified

Description: SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.

Immunogen: A portion of amino acids 313-343 from the human protein was used as the immunogen for this SPHK1 antibody.

Storage: Aliquot the SPHK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.