Description
SP600125 | 27023 | Gentaur US, UK & Europe Disrtribition
Category: Phosphodiesterase/Inhibitors / Activators
Application: N/A
Background: N/A
Description: Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.
Product Type: Inhibitor
Shippement Condition: -20°C